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Canine Autologous Cancer Vaccine, or K9-ACV, is a personalized immunotherapy for your pet. Created by Ardent Animal Health, this treatment is a ground-breaking option for dogs with soft tissue cancer. K9-ACV is used to help your dog's immune system recognize the cancer cells and attack them. 

After bringing your dog in for a physical exam, conversations and planning for the administration of K9-ACV can begin. Any operable soft tissue tumor/mass can be used to create a cancer vaccine.

Surgical removal of the tissue is first required, then that tissue is sent to Ardent Animal Health labs for pathology.

Once the tissue has been biopsied, that tissue is then used to create your dog's vaccine.

Killed cancer cells are processed and shipped back to our office where 3 injections, given every 30 days, will be done.

What is the process?
How  does the K9-ACV work?

Cancer cells can be recognized as foreign by the immune system if those cancer cells are presented to the immune system in a manner that “breaks immune tolerance.” Decades of research in mouse and human models have shown that tumor cells are very much like normal cells in that they express self-antigens that the body is taught to ignore early in development and throughout life. An immunosuppressive environment produced by growing tumors promotes an immune response toward the tumor that is ineffective, allowing the tumor to grow unchecked


An appropriately designed vaccine, like K9-ACV, can break this cycle of tumor immunosuppression, generating tumor-specific immune cells that have effective anti-tumor reactivity, improving survival and quality of life in veterinary patients. K9-ACV is specifically designed to make the patient’s tumor or disease appear foreign, thus inducing an effective anti-tumor immune response, like an immune response against viral or bacterial infections. This is the basic theory behind immunotherapy for the treatment of cancer.

Using the therapeutic approach of immunotherapy, the scientists at Ardent Animal Health have developed a cancer vaccine, created personally for your pet that can be incorporated in your pet’s cancer treatment plan. K9-ACV can be used to treat your pet’s cancer independently or in combination with other traditional treatment methods such as chemotherapy or radiation.

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How successful is K9-ACV?

Tumor regression and elimination are a possibility of immunotherapy but the more likely scenario is an increase in survival beyond palliative care. The vaccine was designed from the success of treating human cancer patients with similar immunotherapy approaches. In a recent publication, 85% of patients displayed an increased response against their cancer post-vaccination. Clinical success has been marked across many different cancer types. K9-ACV is designed as an affordable and simple treatment protocol when owners are looking to move beyond the standard of care.

If you have any questions about the K9-ACV, your pet's viability as a K9-ACV candidate, or would like to schedule for an appointment to discuss this option call our office at


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